British No 2 Cameron Norrie has been ruled out of the US Open with a forearm injury.
Norrie has not played since his defeat to Rafael Nadal at the Swedish Open last month.
"I have been working hard to get my body to full health - unfortunately my forearm injury is not recovering as soon as I would have hoped," he said on Instagram.
"Therefore I will not be able to compete in this year's US Open. I'll take some rest and recharge. Can't wait to get back to competing like a dog."
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The 28-year-old has endured a troubled campaign, with injuries denying him the chance from playing at a number of tournaments. He played through the pain barrier while battling a separate wrist problem at the Australian Open in January, where he was beaten by Alexander Zverev in the fourth round.
Norrie, whose ranking has slid down to 46 amid a poor run of form, was recently forced to give up his hopes of competing at the Paris Olympics, withdrawing from his first-round match against Tallon Griekspoor.
The former Wimbledon semi-finalist pulled out of the Canadian Open and this week's Cincinnati Open and now he will miss the final Grand Slam of the year in New York following a further injury setback.
He has been replaced in the main draw by Francisco Comesana of Argentina.
Meanwhile, Marketa Vondrousova has also been forced to withdraw with Croatian Petra Martic moving into the main draw.
The Czech withdrew from the Olympics due to a hand injury, saying her focus was on being ready for the US Open.
Vondrousova won her first Grand Slam title at Wimbledon last year and was the runner-up at the 2019 French Open. She also won a silver medal at the Tokyo Olympics in 2021.
She hasn't played since a shock first-round loss at the All England Club in July, making her the first woman since 1994 to lose her opening match at Wimbledon a year after winning the title.
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